Fioricet (B,A,C) 325mg,50mg,40mg

Brand Names:

• • Fioricet

  • Esgic

  • Orbivan

  • Dolgic Plus (may vary by region)

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Components and Functions:

1. 1. Acetaminophen (Paracetamol)

      • Function: Pain reliever (analgesic) and fever reducer (antipyretic)

      • Mechanism: Works by inhibiting prostaglandin synthesis in the central nervous system.

   2. Butalbital

      • Function: Barbiturate sedative

      • Mechanism: Depresses the central nervous system to produce a calming effect, which can reduce anxiety and muscle tension associated with headaches.

   3. Caffeine

      • Function: Central nervous system stimulant

      • Mechanism: Constricts dilated blood vessels in the brain, which are believed to contribute to headache pain; also enhances the effects of acetaminophen.

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Typical Dosage (for Adults):

• • Acetaminophen: 325–650 mg

  • Butalbital: 50 mg

  • Caffeine: 40 mg
    Taken every 4 hours as needed. Do not exceed 6 tablets or capsules per day.

Dosage may vary depending on formulation and patient-specific factors. Always follow prescribing instructions.

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Uses:

• • Tension headaches

  • Migraine headaches (off-label in some cases)

  • Muscle contraction headaches

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Common Side Effects:

• • Drowsiness

  • Dizziness

  • Lightheadedness

  • Nausea

  • Abdominal pain

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Serious Side Effects (Seek medical attention):

• • Shortness of breath

  • Liver damage (especially with acetaminophen overdose)

  • Allergic reactions (rash, itching, swelling)

  • Mood or behavior changes

  • Signs of barbiturate dependence or withdrawal

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Warnings and Precautions:

• • Liver Toxicity: High doses of acetaminophen can cause severe liver damage. Avoid alcohol while taking this medication.

  • Addiction/Dependence: Butalbital is habit-forming. Risk increases with prolonged use or high doses.

  • Drug Interactions: May interact with sedatives, alcohol, antidepressants, and other CNS depressants.

  • Pregnancy/Breastfeeding: Use only if clearly needed; butalbital can harm the fetus or newborn.

  • Driving and Operating Machinery: Can impair alertness and coordination.

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Contraindications:

• • Allergy to any of the components

  • Porphyria (a rare blood disorder)

  • Severe liver disease

  • History of substance abuse (use with extreme caution)

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Overdose Symptoms:

• • Acetaminophen: Nausea, vomiting, loss of appetite, sweating, confusion, jaundice (yellowing skin/eyes)

  • Butalbital: Slow or shallow breathing, unconsciousness, coma

  • Caffeine: Restlessness, rapid heartbeat, muscle tremors

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Storage:

• • Store at room temperature away from moisture and light.

  • Keep out of reach of children and pets.

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Important Notes:

• • Do not use for more than a few days unless directed by a doctor.

  • Chronic use can lead to medication-overuse headaches (rebound headaches).

  • Always consult a healthcare provider before combining with other medications or supplements.